紀雅惠

YH Chi 2紀雅惠  研究員
生技與藥物研究所
Email: ychi@nhri.edu.tw

 

EDUCATION

  • Ph.D., Chemistry, National Tsing Hua University, Taiwan. (1998-2002)
  • Visiting graduate student, Internal Medicine, Ohio State University, USA. (2000-2001)
  • B.S., Chemistry, National Taiwan Normal University, Taiwan. (1994-1998)

POSTGRADUATE TRAINING

  • Postdoctoral Fellowship with Kuan-Teh Jeang, Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, USA.(2003/07-2008/05)
  • Postdoctoral Fellowship with Tsu-An Hsu, Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taiwan.(2003/03-2003/07)

PROFESSIONAL EXPERIENCES

  • Investigator, Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taiwan(2021/10- present)
  • Associate Investigator, Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taiwan (2014/09- 2021/09)
  • General Secretary, the Chinese Society of Cell and Molecular Biology (2017/04- 2021/03)
  • Associate Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Taiwan (2014/01- 2014/09)
  • Assistant Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Taiwan (2008/05-2013/12)

RESEARCH INTERESTS

  1. Discovery and development of anti-cancer drugs
  2. Cell cycle regulation in human diseases including cancer and aging-associated disorders
  3. Development of aging and anti-aging mouse models
  4. Nuclear envelope proteins in human diseases and development

HONORS AND AWARDS

2020  FutureTech Breakthrough Award, Taiwan. (co-awardee)

2018  The 15th National Innovation Award in the Academic Research Category, Taiwan.

2014   Young Investigator Award, National Health Research Institutes, Taiwan.

2012   50th Ten Outstanding Young Persons (Taiwan)

2012   Taiwan Promising Women in Science

2008   The 14th Fellows Award for Research Excellence, National Institutes of Health, USA.

2007   The 13th Fellows Award for Research Excellence, National Institutes of Health, USA.

1998   Nominee, The Phi Tau Phi Scholastic Honor Society, Taiwan.

1996   The 8th Yuan-Tseh Lee Chemistry Scholarship, Taiwan.

MEMBERSHIPS IN PROFESSIONAL ORGANIZTIONS

2019-present   Member, American Association for Cancer Research

2019-2020   Member, American Society of Clinical Oncology

2015-present   Member, Taiwan Society of Virology

2013-present Member, The Chinese Society of Cell and Molecular Biology

2013-present   Member, American Society for Molecular Biology and Biochemistry

2005-present   Member, Society of Chinese Bioscientists in America.

2004-present   Member, The American Society for Cell Biology.

1999-2002     Member, Chinese Biophysical Society.

TEACHING ACTIVITIES

2022    “Application of AI in drug discovery and precision medicine”, National Cheng Kung University, Taiwan

2020    “Overviews on Target Therapies”, China Medical University, Taiwan

2019-present    “Molecular Biology”, National Union University, Taiwan

2019-2020    “Key Technologies in Drug Discovery and Development”, National Central University, Taiwan

2016-2018    “Aging Translational Medicine”, China Medical University, Taiwan

2011-present    “Molecular Biology of Aging”, National Tsing-Hua University, Taiwan

2010-present    “Molecular Biology of Aging”, China Medical University, Taiwan

2010-2018    “Cellular Signaling”, National Defense University, Taiwan

2009-2016    “Cancer Biology”, National Central University, Taiwan

2010-2013    “Stem Cell Biology”, National Tsing-Hua University, Taiwan

PUBLICATIONS

Original Investigations

  1. Hung, M. C., Wang, W. P. and *Chi, Y. H. AKT phosphorylation as a predictive biomarker for PI3K/mTOR dual inhibition-induced proteolytic cleavage of mTOR companion proteins in small cell lung cancer. (2022) Cell & Bioscience (accepted)
  2. *Chi, Y. H., Wang, W. P., Hung, M. C., Liou, G. G., Wang, J. Y. and Chao, G. P. H. Deformation of the nucleus by TGFb1 via the remodeling of nuclear envelope and histone isoforms. (2022) Epigenetics & Chromatin. 15(1):1 *correspondence
  3. *#Chi, Y. H., #Yeh, T. K., Ke, Y. Y., Lin, W. H., Tsai, C. H., Wang, W. P., Chen, Y. T., Su, Y. C., Wang, P. C., Chen, Y. F., Wu, Z. W., Yeh, J. Y., Hung, M. C., Wu, M. H., Wang, J. Y., Chen, C. P., Song, J. S., Shih, C., Chen, C. T., *Chang, C. P. (2021) Discovery and synthesis of a pyrimidine-based Aurora kinase inhibitor to reduce levels of MYC oncoproteins. J. Med. Chem. 64(11):7312-7330 *correspondence, #first-author
  4. Huang, J. M., Wang, S. Y., Lai, M. R., Tseng, Y. K., *Chi, Y. H. and *Huang, L. M. (2021) Development of a respiratory syncytial virus vaccine using human hepatitis B core-based virus-like particles to induce mucosal immunity. Vaccine, 39(24):3259-3269.  *correspondence
  5. Hieda, M., Matsumoto, T., Isobe, M., Kurono, S., Kaneko, Y., Kametaka S., Wang, J. Y., Chi, Y. H., Kameda K., Kimura H., Matsuura N., Matsuura S. (2021) The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal. Sci. Rep. 11(1):5358.
  6. Teng, Y. C., Wang, J. Y., *Chi, Y. H. and *Tsai, T. F. (2020) Exercise and the Cisd2 prolongevity gene: two promising strategies to delay the aging of skeletal muscle. Int. J. Mol. Sci. 21(23):9059 *correspondence
  7. Fan, J. R., You, L. R., Wang, W. J., Huang, W. S., Chu, C. T., Chi, Y. H. and Chen, H. C. (2020) Lamin A-mediated nuclear lamina integrity is required for proper ciliogenesis. EMBO Rep. 21(10):e49680.
  8. #Wang, W. P., #Wang, J. Y., Lin, W. H., Kao, C. H., Hung, M. C., Teng, Y. C., Tsai, T. F. and *Chi, Y. H. (2020) Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis. #equal contribution, *correspondence Aging Cell Feb;19(2):e13090. #equal contribution, *correspondence
  9. #You, M. S., #Wang, W. P., Wang, J. Y., Jiang, Y. J. and *Chi, Y. H. (2019) Sun1 mediates interkinetic nuclear migration and Notch signaling in the neurogenesis of zebrafish. Stem Cells Dev. 28(16):1116-1127. #equal contribution, *correspondence
  10. Ko, S.H., Liau, Y. J., Chi, Y. H., Lai, M. J., Chiang, Y. P., Lu, C. Y., Chang, L. Y., Tarn, W. Y., Huang, L. M. (2019) Interference of DNAJB6/MRJ Isoform Switch by Morpholino Inhibits Replication of HIV-1 and RSV. Mol. Ther. Nucleic Acids 14:251-261.
  11. Ke, Y. Y., Chang, C. P., Lin, W. H., Tsai, C. H., Chiu, I. C., Wang, W. P., Wang, P. C., Chen, P. Y., Lin, W. H., Chang, C. F., Kuo, P. C., Song, J. S., Shih C., *Hsieh, H. P. and *Chi, Y. H. (2018) Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition. Eur. J. Med. Chem. 151:533-545. *correspondence
  12. Huang, D. T., Lu, C. Y., Chi, Y. H., Li, W. L., Chang, L. Y., Lai, M. J., Chen, J. S., Hsu, W. M., Huang, L. M. (2017) Adaptation of influenza A (H7N9) virus in primary human airway epithelial cells. Sci Rep. 7(1):11300.
  13. Chen, H. C., Chin, Y. F., Lundy, D. J., Liang, C. T., Chi, Y. H., Kuo, P., Hsieh, P. C. H. (2017) Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis. Sci Rep. 7(1):7372.
  14. Ding, Z. Y., Wang, Y. H., Huang, Y. C., Lee, M. C., Tseng, M. J., Chi, Y. H., and Huang, M. L. (2017) Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture. J. Cell Biol. 216(9):2827-2841.
  15. Huang, D. T., Lu, C. Y., Shao, P. L., Chang, L. Y., Wang, J. Y., Chang, Y. H., Lai, M. J., Chi, Y. H., Huang, L. M. (2017) In vivo inhibition of influenza A virus replication by RNA interference targeting the PB2 subunit via intratracheal delivery. PLoS One 12(4):e0174523.
  16. Lee D. C., Chen, J. H., Hsu, T. Y., Chang, L. H., Chang, H., Chi, Y. H. and Chiu, I.M. (2017) Neural stem cells promote nerve regeneration through IL12-induced Schwann cell differentiation. Mol. Cell Neurosci. 79: 1-11.
  17. Lin, H. Y., Lee, D. C., Wang, H. D., Chi, Y. H. and Chiu, I. M. (2015) Activation of FGF1B promoter and FGF1 are involved in cardiogenesis through the signaling of PKC, but not MAPK. Stem Cells Dev. 24(24):2853-63.
  18. Wang, J. Y., Yu, I. S., Huang, C. C., Chen, C. Y., Wang, W. P., Lin, S. W., Jeang, K. T. and *Chi, Y. H. (2015) Sun1 deficiency leads to cerebellar ataxia in mice. Disease Models & Mechanisms 8(8), 957-967. *correspondence
  19. #Chiang, Y. P., #Sheng, W. H., #Shao, P. L., #Chi, Y. H., Chen, Y. M., Huang, S. W., Shih, S. M., Chang, L. Y., Lu, C. Y., Chang, S. C., Hung, C. C., Huang, L. M. (2014) Large isoform of mammalian relative of DnaJ is a major determinant of human susceptibility to HIV-1 infection. EBioMedicine 1(2-3), 126-132. #contributed equally
  20. Chen, Z. J., Wang, W. W., Chen, Y. C., Wang, J. Y., Lin, W. H., Tai, L. A., Liou, G. G., Yang, C. S. and *Chi, Y. H. (2014) Dysregulated interactions between lamin A and SUN1 induces abnormalities in the nuclear envelope and endoplasmic reticulum in progeric laminopathies. J. Cell Sci. 127(Pt 8):1792-1804. *correspondence
  21. Shiao, H. Y., Coumar, M. S., Chang, C. W., Ke, Y. Y., Chi, Y. H., Chu, C. Y., Sun, H. Y., Chen, C. H., Lin, W. H., Fung, K. S., Kuo, P. C., Huang, C. T., Chang, K. Y., Lu, C. T., Hsu, J. T., Chen, C. T., Jiang, W. T., Chao, Y. S., Hsieh, H. P. (2013) Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor. J. Med. Chem. 56(13):5247-60.
  22. Wu, J. M., Chen, C. T., Coumar, M. S., Lin, W. H., Chen, Z. J., Hsu, J. T. -A., Peng, Y. H., Shiao, H. Y., Lin, W. H., Chu, C. Y., Wu., J. S., Lin, C. T., Chen, C. P., Hsueh, C. C., Chang, K. Y., Huang, C. Y., Chao, Y. S., *Wu, S. Y., *Hsieh, H. P. and *Chi, Y. H.(2013) Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules. Proc Natl Acad Sci USA. 110(19):E1779-87. *correspondence
  23. Wang, W. P. Tzeng, T. Y., Wang, J. Y., Lee, D. C., Lin, Y. H., Wu, P. C., Chen, Y. P., Chiu, I. M. and *Chi Y. H. (2012) The EP300, KDM5A, KDM6A and KDM6B chromatin regulators cooperate with KLF4 in the transcriptional activation of POU5F1. PLoS One 7(12):e52556. *correspondence
  24. *Chi, Y. H., Chen, C. Y., Jeang, K. T. (2012) Reversal of laminopathies: the curious case of SUN1. Nucleus 3(5), 418-421. *correspondence
  25. Chang, T. C., Liu, C. C., Hsing, E. W., Liang, S. M., Chi, Y. H., Sung, L. Y., Lin, S. P., Shen, T. L., Ko, B. S., Yen, B. L., Yet, S. F., Wu, K. K., Liou, J. Y. (2012) 14-3-3σ Regulates β-Catenin-Mediated Mouse Embryonic Stem Cell Proliferation by Sequestering GSK-3β. PLoS One 7(6):e40193.
  26. #Chen, C. Y., #*Chi, Y. H., #Mutalif, R. A., Starost, M. F., Myers, T. G., Anderson, S. A., Stewart, C. L. and *Jeang, K. T. (2012) Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies. Cell 149, 565-577. #contributed equally, *correspondence
  27. Chi, Y. H., Semmes, O. J. and Jeang, K. T. (2011) A proteomic study of TAR-RNA binding protein (TRBP)-associated factors. Cell & Bioscience, 1(1):9.
  28. Shao, P. L., Lu, M. Y., Liau, Y. J., Chao, M. F., Chang, L. Y., Lu, C. Y., Kao, C. L., Chang, S. Y., *Chi, Y. H. and *Huang, L. M. (2011) Argonaute-2 enhances suppression of cytomegalovirus replication by polycistronic short hairpin RNAs targeting UL46, UL70 and UL122. Antiviral Therapy 16, 741-749. *correspondence
  29. Chi, Y. H., Cheng, L. I., Myers, T., Ward, J. M., Williams, E., Su, Q., Faucette, L., Wang, J. Y. and Jeang, K. T. (2009) Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA. Development 136, 965-973.
  30. Chi, Y. H., Chen, Z. J. and Jeang, K. T. (2009) The nuclear envelopathies and human diseases. J. Biomed. Sci. 16:96.
  31. Chi, Y. H., Ward, J. M., Cheng, I. L. and Jeang, K. T. (2009) Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice. Intl. J. Cancer 124, 1483-1489.
  32. Chi, Y. H., Haller, K., Ward, M. D., Semmes, O. J., Li, Y. and Jeang, K. T. (2008) Requirements for protein phosphorylation and the kinase activity of Polo-like kinase 1 (Plk1) for the kinetochore function of mitotic arrest deficiency protein 1 (Mad1). J. Biol. Chem. 283, 35834-35844.
  33. Chi, Y. H., Haller, K., Peloponese, J. M., Jeang, K. T. (2007) Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes. J. Biol. Chem. 282, 27447-27458.
  34. Chi, Y. H., Jeang, K. T. Aneuploidy and cancer. (2007) J. Cell. Biochem. 102, 531-538.
  35. Sheleg, S. V., Peloponese, J. M., Chi, Y. H., Li, Y., Eckhaus, M. and Jeang, K. T. (2007) Evidence for co-operative transforming activity of human pituitary tumor transforming gene (PTTG) and HTLV-1 Tax. J. Virology 81, 7894-7901.
  36. #Iwanaga, Y., #Chi, Y. H., #Miyazato, A., Sergey S., Haller, K., Peloponese, J. M. Jr., Li, Y.; Ward, J. M., Benezra, R. and Jeang, K. T. (2007) Heterozygous deletion of Mad 1 increases the incidence of tumors in mice. Cancer Res. 67, 160-167. #contributed equally
  37. Haller, K., Kibler, K. V., Kasai, T., Chi, Y. H., Peloponese, J. M., Yedavalli, V. S., Jeang, K. T. (2006) The N-terminus of rodent and human MAD1 confers species-specific stringency to spindle assembly checkpoint. Oncogene 25, 2137-2147.
  38. Yedavalli, V. S., Neuveut, C., Chi, Y. H., Kleiman, L., Jeang, K. T. (2004) Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function. Cell 119, 381-392.
  39. Kuo, C. J., Chi, Y. H., Hsu, J. T., Liang, P. H. (2004) Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate. Biochem. Biophys. Res. Commun. 318, 862-867.
  40. Hung, K. W., Kumar, T. K. S., Chi, Y. H., Chiu, I. M., Yu, C. (2004) Molecular cloning, overexpression, and characterization of the ligand-binding D2 domain of fibroblast growth factor receptor. Biochem. Biophys. Res. Commun. 317, 253-258.
  41. Lee, J.C., Chang, C. F., Chi, Y. H., Hwang, D. R., Hsu, J. T. (2004) A reporter-based assay for identifying hepatitis C virus inhibitors based on subgenomic replicon cells. J. Virol. Methods. 116, 27-33.
  42. Srimathi, T., Kumar, T. K. S., Kathir, K. M., Chi, Y. H., Srisailam, S., Lin, W. Y., Chiu, I. M. and Yu, C. (2003) Structurally homologous all beta-barrel proteins adopt different mechanisms of folding. Biophys. J. 85, 459-472.
  43. Srimathi, T., Kumar, T. K. S., Chi, Y. H. and Yu, C. (2002) Characterization of the structure and dynamics of a near-native equilibrium intermediate in the unfolded pathway of an all b-barrel protein. J. Biol. Chem. 277, 47507-47516.
  44. Chi, Y. H., Kumar, T. K. S., Chiu, I. M. and Yu, C. (2002) Investigation of the stability of the human acidic fibroblast growth factor by hydrogen-deuterium exchange. Biochemistry 41, 15350-15359.
  45. Arunkumar, A. I., Kumar, T. K. S., Kathir, K. M., Srisailam, S., Wang, H. M., Leena, P. S. T., Chi, Y. H., Chen, H. C., Wu, C. H., Wu, R. T., Chang, G. G., Chiu, I. M. and Yu, C. (2002) Oligomerization of acidic fibroblast growth factor is not a prerequisite for its cell proliferation activity. Protein Sci. 11, 1050-1061.
  46. Chi, Y. H., Kumar, T. K. S., Chiu, I. M. and Yu, C. (2002) Identification of rare partially unfolded states in equilibrium with the native conformation in an all beta-barrel protein. J. Biol. Chem. 277, 34941-34948.
  47. Arunkumar, A. I., Srisailam, S., Kumar, T. K. S., Kathir, K. M., Chi, Y. H., Wang, H. M., Chang, G. G., Chiu, I. M. and Yu, C. (2002) Structure and stability of an acidic fibroblast growth factor from notophthalmus viridescens. J. Biol. Chem. 277, 46424-46432.
  48. Chi, Y. H., Kumar, T. K. S., Wang, H. M., Ho. M. C., Chiu, I. M. and Yu, C. (2001) Thermodynamic characterization of the human acidic fibroblast growth factor: evidence for cold denaturation. Biochemistry 40, 7746-7753.
  49. Chi, Y. H., Kumar, T. K. S., Chiu, I. M. and Yu, C. (2000) 15N NMR relaxation studies of free and ligand-bound human acidic fibroblast growth factor. J. Biol. Chem. 275, 39444-39450.

Book Chapters

  1. Chi, Y. H. and Jeang, K. T. Human T-cell leukemia virus 1 (HTLV-1) and cellular transformation. (2010) In Jing-Hsiung James Ou editor. Human Oncogenic Viruses. World Scientific Publishing, Hackensack, NJ, USA.
  2. Chi, Y. H. and Jeang, K. T. Chromosome instability and HTLV-1 transformation. (2008) In John Nicholas, Kuan-Teh Jeang and T. -C. Wu editors. Translational Research in Biomedicine, Vol. 1, Human Cancer Viruses. Principles of transformation and pathogenesis. KARGER Publishing, Basel, Switzerland.
  3. Iwanaga, Y., Chi, Y. H. and Jeang, K. T. The spindle assembly checkpoint and cellular transformation. In Miki, T. editor. Signal transduction and cell division. (2005) Research Signpost Publishing, Trivandrum, India.

PATENT

  1. 張竣評、纪雅惠、陳炯東、石全、柯屹又。嘧啶化合物及其醫藥用途。中華民國專利證書證號: I770858 (allow date: July 11, 2022)
  2. 邱英明,纪雅惠,李东庆。利用神经干细胞与IL12p40增强神经再生的方法。China patent number: CN 107148278 B (allow date: June 29, 2021)。
  3. Chun-Ping Chang, Ya-Hui Chi, Chiung-Tong Chen, Chuan Shih, Yi-Yu Ke, “Pyrimidine compounds and their Pharmaceutical Uses”, PCT International Application Number: WO 2021/178485 (date of patent: March 3, 2021).
  4. Chun-Ping Chang, Ya-Hui Chi, Chiung-Tong Chen, Chuan Shih, Yi-Yu Ke, “Pyrimidine compounds and their Pharmaceutical Uses”, US provisional application No. 62986024 (file date: March 6, 2020).
  5. Ing-Ming Chiu, Ya-Hui Chi, Don-Ching Lee, “Method to enhance nerve regeneration utilizing neural stem cells and IL12p40”, Australia patent number: AU 2015303798 (allow date: February 28, 2020).
  6. 邱英明,紀雅惠,李東慶。利用神經幹細胞與IL12p40以增強神經再生的方法。Taiwan patent number: 104126631 (allow date: February 18, 2020)。
  7. Ing-Ming Chiu, Ya-Hui Chi, Don-Ching Lee, “Method to enhance nerve regeneration utilizing neural stem cells and IL12p40”, US patent number: US10,391,149 (allow date August 27, 2019).
  8. Ing-Ming Chiu, Ya-Hui Chi, Don-Ching Lee, “Method to enhance nerve regeneration utilizing neural stem cells and IL12p40”, Canada patent number: CA2958398 (allow date May 14, 2019).
  9. Ing-Ming Chiu, Ya-Hui Chi, Don-Ching Lee, “Method to enhance nerve regeneration utilizing neural stem cells and IL12p40”, Korea patent number: 10-1897422 (allow date September 4, 2018).
  10. Ing-Ming Chiu, Ya-Hui Chi, Don-Ching Lee, “Method to enhance nerve regeneration utilizing neural stem cells and IL12p40”, Japan patent number: JP6339737 (allow date May 18, 2018).
  11. Ing-Ming Chiu, Ya-Hui Chi, Don-Ching Lee, “Method to enhance nerve regeneration utilizing neural stem cells and IL12p40”, WIPO/PCT International publication number: WO2016/023130 A1 (date of patent: February 18, 2016).

INVITED PRESENTATIONS

  1. “Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis ” Presented at The Twenty-seven Symposium on Recent Advances in Cellular and Molecular Biology, Pingtong, Taiwan, January 2020.
  2. “Role of the Nuclear Envelope Proteins in ER Function and Aging” Presented at Asian Society of Aging Research Symposium 2017, Sapporo, Japan, March 2017.
  3. “Role of the Nuclear Envelope Proteins in Progeric Muscle Cell Homeostasis” Presented at Second ICAH-NCGG Symposium, Taipei, Taiwan, April 2016.
  4. “Role of Nuclear Envelope Proteins in Muscle Cell Homeostasis” Presented at First Asian Conference for Frailty and Sarcopenia, Taipei, Taiwan, November 2015.
  5. “Aurora kinases as anticancer drug targets” Presented at the 11th Cross-strait Symposium on Cell Biology, Taiyuan, China, September 2015.
  6. “Dysregulated Affinity of Lamin A to SUN1 Induces Nuclear and Endoplasmic Reticulum Aberrancies in Progeric Laminopathies” Presented at 2014 The Experimental Biology ASBMB Annual Meeting, San Diego, USA, April 2014.
  7. “Reversal of Laminopathies: the curious case of Sun1” Presented at 2014 The 29th Joint Annual Conference of Biomedical Science, National Defense Medical Center, Taipei, Taiwan, March 2014.
  8. “Reversal of Laminopathies: the curious case of Sun1” Presented at The Twenty-second Symposium on Recent Advances in Cellular and Molecular Biology, Pingtong, Taiwan, January 2014.
  9. “Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules” Presented at 2013 NHRI & IBMS Joint International Conference on Inflammation, Cancer and Metabolic Diseases, NHRI, Zhunan, Taiwan.
  10. “Reversal of Laminopathies: the curious case of Sun1” Presented at 2013 Mini-symposium on Mitochondria and Aging, Mackay Medical College, New Taipei City, Taiwan, October 2013.
  11. “The Nuclear Envelope SUN Proteins in Development” Presented at International Mouse Phenotyping Consortium, Academia Sinica, Taipei, Taiwan, May 2013.
  12. “The nuclear envelope protein Sun1: development and aging” Presented at The 2nd Meeting of RNA and Biofunctions-Asia Study RNA biofunctions and Viruses, Fukuoka, Japan, January 2013.
  13. “Dysregulated affinity of Lamin A to SUN1 induces nuclear aberrancies in progeric laminopathies” Presented at Asia-Pacific Developmental Biology Conference (APDBC), Taipei, Taiwan, October 2012.
  14. “Requirement for Sun1 in the meiotic synapsis and expression of reproductive coding and non-coding RNAs” Presented at Tissue Engineering and Regenerative Medicine International Society (TERMIS) annual meeting, Taipei, Taiwan, November 2008.

CONFERENCE PAPERS

  1. “BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification” Presented at American Association for Cancer Research AACR Annual Meeting, Virtual Conference II, June 2020.
  2. “The dual PI3K/mTOR inhibitor GSK2126458 induces programmed cell death in small cell lung cancers through Caspase-mediated cleavage of mTOR protein complexes” Presented at Kinase and Phosphatase Signaling-Cold Spring Harbor Asia, Suzhou, December, 2019.
  3. “An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer” Presented at American Association for Cancer Research AACR Annual Meeting, Atlanta, GA, USA, April 2019.
  4. “Disease-causing mutations of Lamin A lead to loss of calcium homeostasis in the endo/sarcoplasmic reticulum” Presented at 2018 The Experimental Biology ASBMB Annual Meeting, San Diego, USA, April 2018.
  5. “Loss of calcium homeostasis in dystrophic and progeric laminopathies” Presented at Biology of Aging 2017 Gordon Research Conferences, Les Diablerets, Switzerland, July 2017.
  6. “Design and synthesis of BPR1K653 and its derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition” Presented at the American Association for Cancer Research Annual Meeting 2017, Washington DC, April 2017.
  7. “Aberrant Nucleokinesis of Purkinje Cells and Cerebellar Ataxia in SUN deficiency” Presented at the Society of Chinese Bioscientists in America 14th international symposium, Guangzhou, China, July 2013.
  8. “Sun1 and Sun2 are required for nuclear positioning and nuclear migration of neuronal cells in postnatal brain development” Presented at the American Society for Biochemistry and Molecular Biology, San Diego, USA, April 2012.
  9. “The nuclear envelope proteins Sun1 and Sun2 are required for nuclear positioning and nuclear migration in postnatal neurogenesis” Presented at the 4th International Symposium on Ataxia in Taiwan, Taipei, Taiwan, March 2012
  10. “The nuclear envelope and aging: lessons from lamin A and SUN1” Presented at the Society of Chinese Bioscientists in America 13th international symposium, Guangzhou, China, July 2011.
  11. “Removal of Sun1 rescues loss-of-lamin A (Lmna-/-) associated dystrophic lethality” Presented at the American Society for Biochemistry and Molecular Biology, Washington DC, USA, April 2011.
  12. “Requirement of the Nuclear Envelope Protein SUN1 for the Nuclear Envelope Ruffling in the Hunchinson-Gilford Progeria Syndrome” Presented at the American Society for Cell Biology 50th annual meeting, Philadelphia, PA, USA, December 2010.
  13. “Requirement for Sun1 in the meiotic synapsis and expression of reproductive coding and non-coding RNAs” Presented at the American Society for Cell Biology 48th annual meeting, San Francisco, CA, USA, December 2008.
  14. “Polo-like kinase 1 phosphorylates and promotes translocation of MAD1 during G2-M” Presented at the American Society for Cell Biology 46th annual meeting, San Diego, CA, USA, December 2006.
  15. “HTLV-1 Tax transgenic mice develop an array of mesenchymal tumors with unique tissue origins” Presented at the American College of Veterinary Pathologist 57th annual meeting, Tucson, AZ, USA, June 2006.
  16. “MAD1 haplo-insufficiency and tumor development in mice” Presented at the American Society for Cell Biology 45th annual meeting, San Francisco, CA, USA, December 2005.
  17. “Human SUN1 protein plays a critical role in maintaining nuclear integrity” Presented at the American Society for Cell Biology 44th annual meeting, Washington D. C., USA, December 2004.
  18. “Investigation of the structural stability of the human acidic fibroblast growth factor by hydrogen-deuterium exchange” Presented at XXth International Conference on Magnetic Resonance in Biological Systems, Toronto, Canada, August 2002.
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