Ya Hui Chi

YH Chi 2Ya-Hui Chi, Ph.D.
Investigator
Institute of Biotechnology and Pharmaceutical Research
Email: ychi@nhri.edu.tw

 

EDUCATION

  • Ph.D., Chemistry, National Tsing Hua University, Taiwan. (1998-2002)
  • Visiting graduate student, Internal Medicine, Ohio State University, USA. (2000-2001)
  • B.S., Chemistry, National Taiwan Normal University, Taiwan. (1994-1998)

PROFESSIONAL EXPERIENCES

  • Secretary General, International Federation for Cell Biology (2023/01-present)
  • Chief, Student Affairs Office, Department of Research Planning and Development, National Health Research Institutes, Taiwan (2022/10-present)
  • Investigator, Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taiwan(2021/10- present)
  • Associate Investigator, Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taiwan (2014/09- 2021/09)
  • Associate Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Taiwan (2014/01- 2014/09)
  • Assistant Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Taiwan (2008/05-2013/12)
  • Postdoctoral Fellow, National Institute of Allergy and Infectious Disease, National Institutes of Health, USA (2003/07-2008/05)
  • Postdoctoral Fellow, Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taiwan (2003/03-2003/07)

RESEARCH INTERESTS

The development and maintenance of normal tissues and organs requires an adequate balance in internal, external and chemical conditions to maintain cellular homeostasis. Defects in any of these basic processes can lead to disease. For example, uncontrolled cell proliferation or failure to initiate programmed cell death can lead to cancer. On the other hand, persistent cell cycle arrest triggered by intrinsic and extrinsic stimuli would causes cell senescence, a process of deterioration with age. We are interested in understanding the molecular processes that regulate the live and death of cells. We also create therapeutic molecular entities for the treatment of aging-associated diseases including cancer. Current research focus in the laboratory include:

  1. Discovery and development of anti-cancer drugs that target cancer driver proteins
  2. Understanding cell cycle regulation in human diseases including cancer and aging-associated disorders
  3. Development of aging and anti-aging mouse models
  4. Discovery and development of drugs combating aging-associated muscle loss

HONORS AND AWARDS

  • FutureTech Breakthrough Award, Taiwan (2020) 未來科技突破獎
  • The 15th National Innovation Award in the Academic Research Category, Taiwan (2018) 國家新創獎
  • Young Investigator Award, National Health Research Institutes, Taiwan (2014) 國家衛生研究院年輕學者著作獎
  • 50th Ten Outstanding Young Persons, Taiwan (2012) 十大傑出青年
  • Taiwan Promising Women in Science (2012) 女科學家新秀獎
  • The 14th Fellows Award for Research Excellence, National Institutes of Health, USA (2008) 美國國家衛生院博士後優秀論文獎
  • The 13th Fellows Award for Research Excellence, National Institutes of Health, USA (2007) 美國國家衛生院博士後優秀論文獎

SELECTED PUBLICATIONS

  1. Hsiao, W. C., Niu, G. H., Lo, C. F., Wang, J. Y., Chi, Y. H., Huang, W. C., Tung, C. W., Sung, P. J., *Tsou, L. K., *Zhang, M. M. Marine Diterpenoid Targets STING Palmitoylation. (2023) Communications Chemistry 6(1):153.
  2. #Hung, M. C., Wang, #W. P. and *Chi, Y. H. AKT phosphorylation as a predictive biomarker for PI3K/mTOR dual inhibition-induced proteolytic cleavage of mTOR companion proteins in small cell lung cancer. (2022) Cell & Bioscience 12(1):122.
  3. *Chi, Y. H., Wang, W. P., Hung, M. C., Liou, G. G., Wang, J. Y. and Chao, G. P. H. Deformation of the nucleus by TGFb1 via the remodeling of nuclear envelope and histone isoforms. (2022) Epigenetics & Chromatin. 15(1):1.
  4. *#Chi, Y. H., #Yeh, T. K., Ke, Y. Y., Lin, W. H., Tsai, C. H., Wang, W. P., Chen, Y. T., Su, Y. C., Wang, P. C., Chen, Y. F., Wu, Z. W., Yeh, J. Y., Hung, M. C., Wu, M. H., Wang, J. Y., Chen, C. P., Song, J. S., Shih, C., Chen, C. T., *Chang, C. P. (2021) Discovery and synthesis of a pyrimidine-based Aurora kinase inhibitor to reduce levels of MYC oncoproteins. J. Med. Chem. 64(11):7312-7330.
  5. Huang, J. M., Wang, S. Y., Lai, M. R., Tseng, Y. K., *Chi, Y. H. and *Huang, L. M. (2021) Development of a respiratory syncytial virus vaccine using human hepatitis B core-based virus-like particles to induce mucosal immunity. Vaccine, 39(24):3259-3269.
  6. Hieda, M., Matsumoto, T., Isobe, M., Kurono, S., Kaneko, Y., Kametaka S., Wang, J. Y., Chi, Y. H., Kameda K., Kimura H., Matsuura N., Matsuura S. (2021) The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal. Sci. Rep. 11(1):5358.
  7. Teng, Y. C., Wang, J. Y., *Chi, Y. H. and *Tsai, T. F. (2020) Exercise and the Cisd2 prolongevity gene: two promising strategies to delay the aging of skeletal muscle. Int. J. Mol. Sci. 21(23):9059.
  8. Fan, J. R., You, L. R., Wang, W. J., Huang, W. S., Chu, C. T., Chi, Y. H. and Chen, H. C. (2020) Lamin A-mediated nuclear lamina integrity is required for proper ciliogenesis. EMBO Rep. 21(10):e49680.
  9. #Wang, W. P., #Wang, J. Y., Lin, W. H., Kao, C. H., Hung, M. C., Teng, Y. C., Tsai, T. F. and *Chi, Y. H. (2020) Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis. Aging Cell 19(2):e13090.
  10. #You, M. S., #Wang, W. P., Wang, J. Y., Jiang, Y. J. and *Chi, Y. H. (2019) Sun1 mediates interkinetic nuclear migration and Notch signaling in the neurogenesis of zebrafish. Stem Cells Dev. 28(16), 1116-1127.
  11. Ko, S.H., Liau, Y. J., Chi, Y. H., Lai, M. J., Chiang, Y. P., Lu, C. Y., Chang, L. Y., Tarn, W. Y., Huang, L. M. (2019) Interference of DNAJB6/MRJ Isoform Switch by Morpholino Inhibits Replication of HIV-1 and RSV. Mol. Ther. Nucleic Acids 14, 251-261.
  12. #Ke, Y. Y., #Chang, C. P., Lin, W. H., Tsai, C. H., Chiu, I. C., Wang, W. P., Wang, P. C., Chen, P. Y., Lin, W. H., Chang, C. F., Kuo, P. C., Song, J. S., Shih C., *Hsieh, H. P. and *Chi, Y. H. (2018) Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition. Eur. J. Med. Chem. 151, 533-545.
  13. Huang, D. T., Lu, C. Y., Chi, Y. H., Li, W. L., Chang, L. Y., Lai, M. J., Chen, J. S., Hsu, W. M., Huang, L. M. (2017) Adaptation of influenza A (H7N9) virus in primary human airway epithelial cells. Sci Rep. 7(1):11300.
  14. Chen, H. C., Chin, Y. F., Lundy, D. J., Liang, C. T., Chi, Y. H., Kuo, P., Hsieh, P. C. H. (2017) Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis. Sci Rep. 7(1):7372.
  15. Ding, Z. Y., Wang, Y. H., Huang, Y. C., Lee, M. C., Tseng, M. J., Chi, Y. H., and Huang, M. L. (2017) Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture. J. Cell Biol. 216(9), 2827-2841.
  16. Huang, D. T., Lu, C. Y., Shao, P. L., Chang, L. Y., Wang, J. Y., Chang, Y. H., Lai, M. J., Chi, Y. H., Huang, L. M. (2017) In vivo inhibition of influenza A virus replication by RNA interference targeting the PB2 subunit via intratracheal delivery. PLoS One 12(4):e0174523.
  17. Lee D. C., Chen, J. H., Hsu, T. Y., Chang, L. H., Chang, H., Chi, Y. H. and Chiu, I.M. (2017) Neural stem cells promote nerve regeneration through IL12-induced Schwann cell differentiation. Mol. Cell Neurosci. 79, 1-11.
  18. Lin, H. Y., Lee, D. C., Wang, H. D., Chi, Y. H. and Chiu, I. M. (2015) Activation of FGF1B promoter and FGF1 are involved in cardiogenesis through the signaling of PKC, but not MAPK. Stem Cells Dev. 24(24), 2853-2863.
  19. Wang, J. Y., Yu, I. S., Huang, C. C., Chen, C. Y., Wang, W. P., Lin, S. W., Jeang, K. T. and *Chi, Y. H. (2015) Sun1 deficiency leads to cerebellar ataxia in mice. Disease Models & Mechanisms 8(8), 957-967.
  20. #Chiang, Y. P., #Sheng, W. H., #Shao, P. L., #Chi, Y. H., Chen, Y. M., Huang, S. W., Shih, S. M., Chang, L. Y., Lu, C. Y., Chang, S. C., Hung, C. C., Huang, L. M. (2014) Large isoform of mammalian relative of DnaJ is a major determinant of human susceptibility to HIV-1 infection. EBioMedicine 1(2-3), 126-132.
  21. Chen, Z. J., Wang, W. P., Chen, Y. C., Wang, J. Y., Lin, W. H., Tai, L. A., Liou, G. G., Yang, C. S. and *Chi, Y. H. (2014) Dysregulated interactions between lamin A and SUN1 induces abnormalities in the nuclear envelope and endoplasmic reticulum in progeric laminopathies. J. Cell Sci. 127(Pt 8), 1792-1804.
  22. Shiao, H. Y., Coumar, M. S., Chang, C. W., Ke, Y. Y., Chi, Y. H., Chu, C. Y., Sun, H. Y., Chen, C. H., Lin, W. H., Fung, K. S., Kuo, P. C., Huang, C. T., Chang, K. Y., Lu, C. T., Hsu, J. T., Chen, C. T., Jiang, W. T., Chao, Y. S., Hsieh, H. P. (2013) Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor. J. Med. Chem. 56(13), 5247-5260.
  23. Wu, J. M., Chen, C. T., Coumar, M. S., Lin, W. H., Chen, Z. J., Hsu, J. T. -A., Peng, Y. H., Shiao, H. Y., Lin, W. H., Chu, C. Y., Wu., J. S., Lin, C. T., Chen, C. P., Hsueh, C. C., Chang, K. Y., Huang, C. Y., Chao, Y. S., *Wu, S. Y., *Hsieh, H. P. and *Chi, Y. H. (2013) Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules. Proc Natl Acad Sci USA. 110(19):E1779-87.
  24. Wang, W. P. Tzeng, T. Y., Wang, J. Y., Lee, D. C., Lin, Y. H., Wu, P. C., Chen, Y. P., Chiu, I. M. and *Chi Y. H. (2012) The EP300, KDM5A, KDM6A and KDM6B chromatin regulators cooperate with KLF4 in the transcriptional activation of POU5F1. PLoS One 7(12):e52556.
  25. *Chi, Y. H., Chen, C. Y., Jeang, K. T. (2012) Reversal of laminopathies: the curious case of SUN1. Nucleus 3(5), 418-421.
  26. Chang, T. C., Liu, C. C., Hsing, E. W., Liang, S. M., Chi, Y. H., Sung, L. Y., Lin, S. P., Shen, T. L., Ko, B. S., Yen, B. L., Yet, S. F., Wu, K. K., Liou, J. Y. (2012) 14-3-3σ Regulates β-Catenin-Mediated Mouse Embryonic Stem Cell Proliferation by Sequestering GSK-3β. PLoS One 7(6):e40193.
  27. #Chen, C. Y., #*Chi, Y. H., #Mutalif, R. A., Starost, M. F., Myers, T. G., Anderson, S. A., Stewart, C. L. and *Jeang, K. T. (2012) Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies. Cell 149, 565-577.
  28. Chi, Y. H., Semmes, O. J. and Jeang, K. T. (2011) A proteomic study of TAR-RNA binding protein (TRBP)-associated factors. Cell & Bioscience, 1(1):9.
  29. Shao, P. L., Lu, M. Y., Liau, Y. J., Chao, M. F., Chang, L. Y., Lu, C. Y., Kao, C. L., Chang, S. Y., *Chi, Y. H. and *Huang, L. M. (2011) Argonaute-2 enhances suppression of cytomegalovirus replication by polycistronic short hairpin RNAs targeting UL46, UL70 and UL122. Antiviral Therapy 16, 741-749.
  30. Chi, Y. H., Cheng, L. I., Myers, T., Ward, J. M., Williams, E., Su, Q., Faucette, L., Wang, J. Y. and Jeang, K. T. (2009) Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA. Development 136, 965-973.

PATENT

  1. 張竣評、纪雅惠、陳炯東、石全、柯屹又。嘧啶化合物及其醫藥用途。中華民國專利證書證號: I770858 (allow date: July 11, 2022)
  2. 邱英明,纪雅惠,李东庆。利用神经干细胞与IL12p40增强神经再生的方法。China patent number: CN 107148278 B (allow date: June 29, 2021)。
  3. Chun-Ping Chang, Ya-Hui Chi, Chiung-Tong Chen, Chuan Shih, Yi-Yu Ke, “Pyrimidine compounds and their Pharmaceutical Uses”, PCT International Application Number: WO 2021/178485 (date of patent: March 3, 2021).
  4. Chun-Ping Chang, Ya-Hui Chi, Chiung-Tong Chen, Chuan Shih, Yi-Yu Ke, “Pyrimidine compounds and their Pharmaceutical Uses”, US provisional application No. 62986024 (file date: March 6, 2020).
  5. Ing-Ming Chiu, Ya-Hui Chi, Don-Ching Lee, “Method to enhance nerve regeneration utilizing neural stem cells and IL12p40”, Australia patent number: AU 2015303798 (allow date: February 28, 2020).
  6. 邱英明,紀雅惠,李東慶。利用神經幹細胞與IL12p40以增強神經再生的方法。Taiwan patent number: 104126631 (allow date: February 18, 2020)。
  7. Ing-Ming Chiu, Ya-Hui Chi, Don-Ching Lee, “Method to enhance nerve regeneration utilizing neural stem cells and IL12p40”, US patent number: US10,391,149 (allow date August 27, 2019).
  8. Ing-Ming Chiu, Ya-Hui Chi, Don-Ching Lee, “Method to enhance nerve regeneration utilizing neural stem cells and IL12p40”, Canada patent number: CA2958398 (allow date May 14, 2019).
  9. Ing-Ming Chiu, Ya-Hui Chi, Don-Ching Lee, “Method to enhance nerve regeneration utilizing neural stem cells and IL12p40”, Korea patent number: 10-1897422 (allow date September 4, 2018).
  10. Ing-Ming Chiu, Ya-Hui Chi, Don-Ching Lee, “Method to enhance nerve regeneration utilizing neural stem cells and IL12p40”, Japan patent number: JP6339737 (allow date May 18, 2018).
  11. Ing-Ming Chiu, Ya-Hui Chi, Don-Ching Lee, “Method to enhance nerve regeneration utilizing neural stem cells and IL12p40”, WIPO/PCT International publication number: WO2016/023130 A1 (date of patent: February 18, 2016).
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